C反应蛋白在急性白血病化疗后粒缺合并感染中的意义

目的：探讨C反应蛋白（CRP）对于急性白血病化疗后粒细胞缺乏患者感染的诊断价值。方法：选择急性白血病化疗后出现粒细胞缺乏患者64例，按照是否有感染及感染程度分为严重感染组（n=12）、非严重感染组（n=34）及未感染组（n=18），检测感染症状出现24h内的血常规及CRP。结果：严重感染组CRP显著高于非严重感染组及未感染组，差异有统计学意义（P〈0．05）；非严重感染组CRP显著高于未感染组，差异有统计学意义（P〈0．05）；严重感染组中性粒细胞绝对值（ANC）低于非严重感染组及未感染组，但差异无统计学意义（P〉0．05）；非严重感染组ANC与未感染组比较，差异无统计学意义（P〉0．05）。结论：CRP可以作为急性白血病化疗后粒细胞缺乏患者合并感染的检测指标，对于感染程度的判断有较好的辅助作用。

Clinical significance of C reactive protein in diagnosis of infection among patients with leukemia after chemotherapy

Objective： To study the value of C reactive protein（CRP） in diagnosis of infection among patients with leukemia, neutropenia after chemotherapy. Methods： Sixty-four patients with leukemia, neutropenia after chemotherapy were divided into three groups： the severe infection group（ n = 12） , the non-serious infection group （ n = 34） and the non- infection group （ n = 18 ）. Blood sample was collected in order to determine the level of CRP and absolute neutrophil count（ANC） at the onset of infection within 24 h. Results： The serum level of CRP in the severe infection group was significantly higher than those in the non-serious infection group and non-infection group （P 〈 0.05 ）. The serum level of CRP in the non- serious infection group was significantly higher than that in the non-infection group （P 〈 0. 05 ）. ANC had no significant difference among the three groups （P 〉 0. 05 ）. Conclusion： The serum level of CRP can be an useful indicator in diagnosing neutropenic infection and severity of infection in patients with leukemia, neutropenia after chemotheralav.