FibroScan对慢性乙型肝炎患者肝纤维化的诊断价值

目的 探讨FibroScan对慢乙肝患者肝纤维化的诊断价值,研究FibroScan与肝脏病理、超声等指标的相关性.方法 研究对象为宁夏医科大学总医院感染科门诊及住院患者共94例,均行肝脏弹性测定,于同期行肝穿病理活检及腹部B超,采用指标综合积分法对超声二维图像行半定量化评分,绘制ROC曲线,以肝穿病理结果为金标准,研究肝硬度等指标对纤维化的诊断价值.结果 慢乙肝患者肝硬度值、超声学指标包括肝实质、被膜、边缘、肝静脉的二维声像图评分及各指标总评分与病理学肝纤维化程度分期间存在一定的相关性,相关系数r分别为0.65、0.52、0.41、0.50、0.56、0.60（P ＜0.01）,ROC曲线下面积分别为0.77、0.64、0.57、0.69、0.72、0.75.结论 肝硬度值与肝脏病理分期存在显著正相关,与超声等联合检测可提高纤维化诊断价值.

Diagnostic Value of FibroScan for Liver Fibrosis in Patients with Chronic Hepatitis B

Objective To explore the diagnostic value of FibroScan for liver fibrosis in patients with CHB and to investigate the reletion between FibroScan and other parameters such as pathological examination, ultrosonic testing. Methods 94 CHB patients treated in general hospital of NingXia medical university were enrolled in this study. All of 94 patients were carried out FibroScan assayand , liver puncture biopsy pathology examina- tion and ultrasound examination. The USG for semiquantitative score were evaluated through indexes and pre- hensive integral method. Results The stiffness parameter and the final score of hepatic parenchyma coming from ultrasonic examination to observe the liver＇s biopsy, capsule, edge and vein had a significant correlation with the pathological degree of liver fibrosis and the related coefficients were 0. 65 ,0. 52 ,0. 41,0. 50 ,0. 56 , 0.60 ,respectively （P 〈 0.05 ）. The ROC curve analysis showed that the areas under the curve for stiffness, hepatic parenchyma to observe the liver＇s biopsy, capsule, edge and vein and theirs total score were 0.77, 0. 64,0.57,0.69,0. 72,0.75. Conclusion Stiffness parameter has good correlation with the pathological de- gree of 1 iver fibrosis. FibroScan has a certain advantage in diagnosis of liver fibrosis.