胰高血糖素瘤两例报道并文献复习

目的：探讨胰高血糖素瘤的临床特点及诊疗方法。方法：回顾分析两例胰高血糖素瘤患者的临床资料及诊疗经过，并结合文献进行分析。结果：两例患者都曾因糖尿病、消瘦、舌炎、坏死松解性游走性红斑等症状就诊于内分泌科及皮肤科，影像学检查提示胰尾占位。两例均行胰体尾及脾脏切除术，术后血糖控制有效，相应伴随症状消失，其中1例患者于术后3年复查CT提示肝脏占位，再次入院行肝右后叶切除、肝左叶肿瘤局部切除及胆囊切除术。结论：胰高血糖素瘤相关临床症状较多，早期诊断较困难，影像学检查对其诊断有一定帮助，外科手术切除仍是其治疗的有效方式。

Analysis of two cases glucagonoma and literature review

Objective： To investigate the clinical features, diagnosis and treatment of glucagonoma. Methods： Two cases of glucagonoma patients in our hospital were analyzed retrospectively. Results： Two patient had received treatment in endocrinology and dermatology, because their symptoms of diabetes, weight loss, glossitis, necrolytic migratory erythema and imaging examination suggested pancreatic tail mass. Therefore, two patients underwent distal pancreatectomy and spleen resection. After surgery, the patients＇ blood glucose was controlled and their corresponding accompanying symptoms disappeared. However, CT results of one patient suggested multiple liver occupying lesions after three years. The patient readmitted for surgery of hepatic right lobectomy and left lobe of tumor local resection and cholecystectomy. Conclusion： The glucagonoma related symptoms are complex and difficult to diagnose early. Imaging examination is helpful for the diagnosis and surgical operation excision is still an effective therapy.