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| 五丹胃福汤对慢性萎缩性胃炎模型大鼠自由基水平的影响 | |
| 引用本文： | 魏国娈,刘新生,邵祖燕,刘福林,胡利民,丁慧芬. 五丹胃福汤对慢性萎缩性胃炎模型大鼠自由基水平的影响[J]. 中国中西医结合消化杂志, 2002, 10(6): 352-354 |
| 作者姓名： | 魏国娈 刘新生 邵祖燕 刘福林 胡利民 丁慧芬 |
| 作者单位： | 1. 天津中医学院96级研究生,天津,300193 2. 广州中医药大学96级研究生,广州,510405 3. 天津中医学院第二临床医学院,天津,300193 4. 天津中医学院病理教研室,广州,510405 |
| 摘 要： | 目的 :研究五丹胃福汤对慢性萎缩性胃炎的作用机制。方法 :用 Wistar大鼠 75只随机分为 5组 ,即正常对照组、造模组、自然恢复组、小剂量治疗组和大剂量治疗组 ,治疗组给予五丹胃福汤进行干预 ,采用单一试剂法检测大鼠胃粘膜及血清超氧化物歧化酶 (SOD)与丙二醛 (MDA)。结果 :五丹胃福汤能够增强萎缩性胃炎大鼠胃粘膜及血清 SOD水平而降低 MDA水平 ,从而减轻自由基对胃粘膜的损害。结论 :五丹胃福汤可有效调节血清及胃粘膜的自由基水平 ,是本方有效治疗萎缩性胃炎的作用机制之一。 |
| 关 键 词： | 降气和胃 理气活血 五丹胃福汤 慢性萎缩性胃炎 丙二醛 超氧化物歧化酶 |
Effect of Wudan Weifu Decoction on the Level of Free Radical in Rats Model of Chronic Atrophic Gastritis |
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| WEI Guoluan,LIU Xinsheng,SHAO Zuyan,et al Postgraduate of Grade ,Tianjin College of TCM,Tianjin. Effect of Wudan Weifu Decoction on the Level of Free Radical in Rats Model of Chronic Atrophic Gastritis[J]. Chinese Journal of Integrated Traditional and Western Medicine on Digestion, 2002, 10(6): 352-354 | |
| Authors: | WEI Guoluan LIU Xinsheng SHAO Zuyan et al Postgraduate of Grade Tianjin College of TCM Tianjin |
| Affiliation: | WEI Guoluan,LIU Xinsheng,SHAO Zuyan,et al Postgraduate of Grade 96,Tianjin College of TCM,Tianjin 300193 |
| Abstract: | Objective: To investigate the mechanism of Wudan Weifu decoction (WWD) in the treatment of chronic atrophic gastritis (CAG). Methods: Seventy-five Wistar rats were divided into 5 groups: normal control group, model group, natural recovery group, low-dose WWD group, high-dose WWD group. The related indexes were tested with single reagent method. Results: WWD could increase the level of SOD in gastric mucosa and plasma, decrease the content of MDA and reduce the injury of free radical to the gastric mucosa. Conclusion: WWD could regulate the levels of free radical in gastric mucosa and plasma of rats with CAG, which might be one of the mechanisms of WWD to treat CAG effectively. |
| Keywords: | Wudan Weifu decoction atrophic gastritis chronic MDA SOD |
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