基于功效和物质基础的附子毒性研究进展

目的为进行与功效和物质基础相关的附子毒性研究提供文献依据和研究思路。方法对附子近20年来国内外相关文献进行整理、分析与归纳。结果目前，附子毒性研究主要集中在生物碱类物质上，对蛋白质、油酸、多糖等成分毒性研究不够深入，更缺乏物质基础与毒性的相关性研究；另外，针对附子功效开展大量药效学研究和机制探讨，但是关于功效与毒性的相关性研究也基本属于空白。结论鉴于中药的毒性是在临床发挥功效的过程中逐渐被认识的，并且与其物质基础种类、含量密切相关，故应在附子功效发挥的同时密切关注毒性的表达，同时在毒性表达的引导下进行物质基础分离与控制，还应注意产生药理作用和毒性反应的药理学性质异同和导致上述反应的物质基础种类异同，才能提出切合临床使用实际的附子毒性预警方案和早期不良反应诊疗措施，以确保附子临床安全应用。

Research Development on Toxicity of Radix Aconite Lateralis Based on Efficacy and Material Basis

Objective To provide literature basis and research idea for the toxicity research of Radix Aconite Lateralis related to the efficacy and material basis. Methods References in the last two decades at home and abroad about Radix Aconite Lateralis were collated, analyzed and summarized. Results Recently, the research on toxicity of Radix Aconite Lateralis was focused on the alkaloids material. The protein, oleic acid, polysaccharide and other substances were not further studied, and the associated study between material basis and toxicity were lacked. On the other hand, a large number of pharmacodynamics and mechanism researches on the efficacy of Radix Aconite Laterah＇s were studied, but the associated study between efficacy and toxicity were in the blank spaces. Conclusion Considering that the toxicity of traditional Chinese medicine was recognized gradually in the process of expressing efficacy and has close relation with material basis＇s varieties and contents, so the expression of efficacy and toxicity should be paid attention at the same time, and to conduct the material basis separation and control under the expression of toxicity. The similarities and differences of pharmacology character of pharmacology efficacy and toxicity and that of material basis varieties that leads to these reactions should also be noticed. Only in this way, could we raise the toxic warning schemes and the diagnosis and treatment measures of adverse reactions about the toxicity of Radix Aconite Laterah＇s in the actual clinical use, to insure the safe use in clinic.