Followup of adolescents initially treated for prepubertal-onset major depressive disorder with imipramine |
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Authors: | C W Hughes S H Preskorn M Wrona R Hassanein S Tucker |
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Institution: | Psychiatric Research Institute, St. Francis Regional Medical Center, Wichita, KS. |
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Abstract: | This preliminary followup of adolescents (n = 16) with prepubertal-onset major depressive disorder (MDD) suggests that a significant number continue to be depressed or possibly depressed (62%) and have moderate to severe ongoing psychosocial adjustment problems. A concomitant diagnosis of conduct or oppositional disorder at index assessment was a risk factor for an increased incidence of interim depressive episodes and more severe psychosocial adjustment problems including alcohol and drug abuse. |
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