Effects of glucocorticosteroids on cultured human skin fibroblasts |
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Authors: | Maria Ponec Corry de Haas Johanna A. Kempenaar Bernard N. Bachra |
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Affiliation: | (1) Department of Dermatology, University Hospital, Rijnsburgerweg 10, Leiden, The Netherlands;(2) Laboratory for Physiological Chemistry, Department of Medical Biochemistry, University of Leiden, Leiden, The Netherlands |
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Abstract: | Summary As previously found, the glucocorticosteroid clobetasol-17-propionate inhibits cell proliferation during the early growth stage of normal baby foreskin fibroblasts and collagen synthesis in confluent cultures of these cells. The degree of inhibition of cell proliferation decreases with increasing cell density and, moreover, is transient.The anabolic steroids nandrolone and nandrolone-phenyl-propionate have similar effects on these cells. Likewise the magnitude of the inhibition is dose-dependent.When present together the two types of drug do not act in an additive manner. Even at low concentrations the anabolic steroids abolish the inhibitory effect of the glucocorticosteroid on cell proliferation. Furthermore, in this case only the inhibitory effect of the glucocorticosteroid on collagen synthesis is found and there is no further increase in this effect due to the presence of the anabolic steroids.Our results imply that the use of low concentrations of anabolic steroids combined with glucocorticosteroids in topical application to the skin may abolish some of the undesirable side effects of the glucocorticosteroids. |
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Keywords: | Glucocorticosteroids Anabolic steroids Fibroblasts Proliferation Collagen synthesis |
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