慢性阻塞性肺疾病患者血清和痰液中表面活性蛋白D的水平及临床意义

目的:探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,AECOPD)患者血清和痰液中表面活性蛋白D(surfactant protein D,SP-D)的水平和临床意义。方法:选取急性加重期COPD(acute exacerbation of COPD,AECOPD)患者34例(A组)、稳定期COPD患者37例(B组)、有嗜烟史的健康人30例(C组)、无嗜烟史的健康人30例(D组)。分别检测4组血清和痰液中的SP-D水平,并分析AECOPD患者血清和痰液SP-D水平的相关性。结果:A、B、C、D组的血清SP-D水平依次为(165.09±16.72)、(126.48±15.64)、(72.85±8.62)、(54.70±7.29)ng/mL,痰液SP-D水平依次为(109.03±18.95)、(133.28±16.36)、(260.04±47.91)、(665.89±117.49)ng/mL;血清和痰液SP-D水平在4组间的差异均有统计学意义(P0.05)。AECOPD患者的血清SP-D水平和痰液SP-D水平呈负相关(r=-0.698,P0.05)。结论:AECOPD患者的血清、痰液SP-D水平呈负相关。血清、痰液SP-D水平的监测有助于临床AECOPD病情的评估。

Serum and Sputum Levels of Surfactant Protein D in Patients with Chronic Obstructive Pulmonary Disease and the Clinical Significance

Objective：To explore the levels and clinical significance of serum and sputum surfactant protein D （SP-D）in pa-tients with chronic obstructive pulmonary disease （AECOPD）.Methods：Thirty-four patients with AECOPD （Group A）,37 patients with stable COPD （Group B）,30 healthy people with smoking history （Group C）,and 30 helthy people without smok-ing history （Group D）were enrolled.SP-D levels in the serum and sputum of the four groups were detected and compared. Moreover,the correlation between serum SP-D level and sputum SP-D level in patients with AECOPD was analyzed.Results：The serum SP-D levels in Group A,Group B,Group C and Group D were （165.09±16.72）ng/mL,（126.48± 15.64）ng/mL, （72.85±8.62）ng/mL and（54.70±7.29）ng/mL,respectively.The sputum SP-D levels in Group A,Group B,Group C and Group D were （109.03 ± 18.95）ng/mL,（133.28± 16.36）ng/mL,（260.04±47.91）ng/mL and（665.89± 117.49）ng/mL. There were significant differences in the levels of serum and sputum SP-D among the four groups（P 〈0.05）.Serum SP-D level and sputum SP-D level in patients with AECOPD were negatively correlated （r=-0.698,P 〈0.05）.Conclusions：The detec-tion of SP-D levels in serum and sputum contributes to the clinical assessment of AECOPD.There is a negative correlation be-tween serum SP-D level and sputum SP-D level in AECOPD patients.