血清降钙素原在儿童急性胰腺炎中的临床意义

目的:探讨血清降钙素原(PCT)在儿童胰腺炎中的临床意义。方法:按《中国急性胰腺炎诊治指南(草案)》将56例急性胰腺炎患儿分为轻型组(MAP组,n=30)和重型组(SAP组,n=26);另选择同期进行健康体检的56例儿童作为正常对照组。检测并比较三组儿童的PCT、C反应蛋白(CRP)、血清淀粉酶(S-Amy)水平。结果:(1)MAP组和SAP组患儿入院24h、48 h、72 h时的PCT水平均较入院时降低(P0.05);MAP组和SAP组患儿入院24 h时的CRP较入院时无明显升高,48h、72 h时的CRP升高明显(P0.05)。SAP组PCT降低及CRP升高的幅度较MAP组明显(P0.05)。MAP组和SAP组间及两组入院24 h、48 h、72 h时的S-Amy水平与入院时比较,差异均无统计学意义。(2)与正常对照组比较,56例AP患儿入院时有68%血清PCT升高,入院24 h时有57%PCT升高;在入院48 h时有30%PCT升高。结论:PCT检测对儿童AP的诊断较为敏感,可为其治疗提供帮助。

Clinical Significance of Serum Procalcitonin in Children with Acute Pancreatitis

Objective：To investigate the clinical significance of procalcitonin（PCT） in children with acute pancreatitis.Methods：Fifty-six children with acute pancreatitis were divided into mild-to-moderate group （MAP group,n =30）and severe group （SAP group,n =26）,according to Chinese guideline of diagnosis and treatment of acute pancreatitis （draft）.And at the same time,other 56 children who underwent healthy physical examination were selected as control group.The levels of PCT,C-reactive protein （CRP） and serum amylase （S-Amy） in 3 groups were detected respectively and compared with each other.Results：（1）PCT levels at 24 h,48 h,72 h after admission were lower than that on admission in MAP and SAP group （P＜ 0.05）.CRP level at 24 h after admission,compared with that on admission,had no significant change in MAP and SAP group.However,it significantly rose at 48 h and 72 h after admission （P＜0.05）.And the range of CRP increase and PCT decrease was more prominent in SAP group than that in MAP group （P＜0.05）.There was no significant difference between the S-Amy levels in MAP group and that in SAP group,as well as between the S-Amy levels at 24 h,48 h,72 h and that on admission in the two groups （P＞0.05）.（2）Compared to the control group,of the 56 patients with acute pancreatitis,68％ had PCT increase on admission,57％ at 24 h after admission and 30％ at 48 h after admission.Conclusions：The PCT detection is sensitive to the diagnosis of acute pancreatitis in children,and conducive to its treatment.