| 早期胃癌淋巴管密度预测淋巴结转移的研究 |
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| 引用本文： | 姜宗丹,张振玉,吴海露,胡可伟,王劲松,赵有财,黄文斌. 早期胃癌淋巴管密度预测淋巴结转移的研究[J]. 现代肿瘤医学, 2012, 20(7): 1410-1412 |
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| 作者姓名： | 姜宗丹 张振玉 吴海露 胡可伟 王劲松 赵有财 黄文斌 |
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| 作者单位： | 1. 南京医科大学附属南京第一医院消化科,江苏南京,210006
2. 南京医科大学附属南京第一医院病理科,江苏南京,210006 |
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| 基金项目： | 南京市医学科技发展专项资金 |
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| 摘 要： | 目的:检测淋巴管内皮标志物D2-40计算早期胃癌淋巴管密度(LVD),探讨LVD与早期胃癌有无淋巴结转移之间的关系.方法:用免疫组化SP染色法,对80例早期胃癌淋巴结未发生转移与20例早期胃癌淋巴结发生转移的癌周检测D2-40标记阳性LVD的表达水平,并进行统计学分析.结果:D2-40标记阳性LVD在早期胃癌伴有淋巴结转移癌周高于早期胃癌不伴有淋巴结转移癌周(P＜0.05),光镜下LVD的截断(cut-off)值为18.50个.结论:早期胃癌伴有淋巴结转移癌周的LVD高于早期胃癌不伴有淋巴结转移癌周,D2-40阳性LVD可用来判断有无淋巴结转移.
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| 关 键 词： | 早期胃癌 淋巴结转移 淋巴管密度 D2-40 |
Lymphatic vessel density marked by D2-40 in early gastric cancers to predict lymph node metastasis |
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| JIANG Zongdan , ZHANG Zhenyu , WU Hailu , HU Kewei , WANG Jinsong , ZHAO Youcai , HUANG Wenbin. Lymphatic vessel density marked by D2-40 in early gastric cancers to predict lymph node metastasis[J]. Journal of Modern Oncology, 2012, 20(7): 1410-1412 |
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| Authors: | JIANG Zongdan ZHANG Zhenyu WU Hailu HU Kewei WANG Jinsong ZHAO Youcai HUANG Wenbin |
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| Affiliation: | 1Department of Gastroenterlolgy;2Department of Pathology,Nanjing First Hospital Affiliated to Nanjing Medical University,Jiangsu Nanjing 210006,China. |
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| Abstract: | Objective:To investigate lymphatic vessel density(LVD)marked by D2-40 and its relationship with lymph node metastasis in early gastric cancers.Methods: Immunohistochemical SP method was used to detect the LVD marked by D2-40 in early gastric cancers without lymph node metastasis(n=80)and with lymph node metastasis(n=20)and all these were analyzed statistically.Results:The LVD marked by D2-40 in early gastric cancers with lymph node metastasis were more than those in early gastric cancers without lymph node metastasis.The cut-off value of mean lymphatic vessel density with LM was 18.50.Conclusion:The LVD marked by D2-40 in early gastric cancers with lymph node metastasis were more than those in early gastric cancers without lymph node metastasis,and the LVD marked by D2-40 in early gastric cancers can predict the lymph node metastasis. |
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| Keywords: | early gastric cancers lymph node metastasis lymphatic vessel density D2-40 |
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