胃癌及癌前病变与幽门螺杆菌感染相关性的临床分析

目的:测定幽门螺杆菌在萎缩肠化生胃炎,异型增生及胃癌中感染情况,探讨Hp与它们的相关性。方法:萎缩肠化生胃炎(A组)患者342例,异型增生(B组)229例,胃癌患者(C组)298例,采用Hp抗体ELISA法检测血清抗Hp-IgG抗体。结果:肠化生患者较非肠化生胃黏膜中的Hp感染多见。异型增生和胃癌的Hp感染率均高于萎缩性胃炎组(P<0.05),异型增生和胃癌两者间的Hp感染率亦存在差异(P<0.05)。幽门螺杆菌感染的萎缩肠化生胃炎及异性增生较非幽门螺杆菌感染者发生癌变的差异性显著,P<0.05;幽门螺杆菌感染的胃癌5年生存期显著短于非感染者,P<0.05。结论:Hp感染与萎缩肠化生胃炎,异型增生及胃癌有密切相关性,并缩短萎缩肠化生胃炎,异型增生癌变时间,缩短胃癌5年生存时间。

Gastric cancer and precancerous lesions associated with Helicobacter pyiori infection

Objective:To determine the Helicobacter pylori infection in atrophic gastritis,intestinal metaplasia,dysplasia and gastric infection.Methods: Atrophic gastritis and intestinal metaplasia(A group)were 342 cases,the opposite sex hyperplasia(B group)229 cases of gastric cancer patients(C group)298 patients,were detected for serum anti-Hp-IgG antibodies by ELISA kit.Results: Dysplasia and gastric cancer with Hp infection rate was higher than the atrophic gastritis group(P<0.05).Helicobacter pylori infection and atrophic gastritis,intestinal metaplasia and hyperplasia of the opposite sex than non-cancerous Helicobacter pylori infection was differ rent significantly,P<0.05;for cancer patients with helicobacter pylori infection,5-year survival rate was significantly shorter than the H.Lo non-infected patients P<0.05.Conclusion: Hp infection and atrophic gastritis,intestinal metaplasia,dysplasia and gastric cancer are closely related,and reduce atrophy gastritis,intestinal metaplasia,dysplasia,shorten the five-year cancer survival rate.