| Survivin-mRNA在肺癌纤维支气管镜活检组织中的表达 |
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| 引用本文： | 魏霞,李婧,石志红,崔亚娟,李洁,马政权. Survivin-mRNA在肺癌纤维支气管镜活检组织中的表达[J]. 现代肿瘤医学, 2012, 20(8): 1618-1621 |
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| 作者姓名： | 魏霞 李婧 石志红 崔亚娟 李洁 马政权 |
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| 作者单位： | 1. 西安市第九医院呼吸科,陕西西安,710054
2. 西安交通大学第一附属医院呼吸科,陕西西安,710061 |
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| 基金项目： | 西安市科技计划项目(编号:HM117 |
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| 摘 要： | 目的:探讨纤维支气管镜活检组织Survivin-mRNA的表达对肺癌诊断的价值。方法:纤维支气管镜活检组织常规病理检查分为肺癌组和良性病变组,同时活检组织用RT-PCR方法检测Survivin-mRNA的表达。结果:46例肺癌组Survivin-mRNA表达明显高于17例肺部良性疾病组(P<0.05);肺癌纤支镜活检组织Survivin-mRNA表达与年龄、性别及组织类型无关(P>0.05);低分化NSCLC Survivin-mRNA表达高于高、中分化NSCLC(P<0.05);Ⅲ+Ⅳ期NSCLCSurvivin-mRNA表达高于I+Ⅱ期NSCLC(P<0.05);SCLC广泛期和局限期Survivin-mRNA表达无显著性差异(P>0.05)。结论:检测纤维支气管镜活检组织Survivin-mRNA的表达对肺癌的诊断,恶性程度判断及预后判断有一定的价值。
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| 关 键 词： | 肺肿瘤 生存素 mRNA 支气管镜 活检 |
Expression of Survivin - mRNA of bronchofiberscope biopsy in lung cancer |
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| WEI Xia , LI Jing , SHI Zhihong , CUI Yajuan , LI Jie , MA Zhengquan. Expression of Survivin - mRNA of bronchofiberscope biopsy in lung cancer[J]. Journal of Modern Oncology, 2012, 20(8): 1618-1621 |
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| Authors: | WEI Xia LI Jing SHI Zhihong CUI Yajuan LI Jie MA Zhengquan |
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| Affiliation: | 1Department of Respiratory Medicine,Xi’an Ninth Hospital,Shaanxi Xi’an 710054,China;2The First Affiliated Hospital,Medical School of Xi’an Jiaotong University,Shaanxi Xi’an 710061,China. |
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| Abstract: | Objective:To investigate the value of Survivin-mRNA expression by bronchofiberscope biopsy in lung cancer.Methods: According to pathological results,bronchofiberscope biopsy samples were divided into lung cancer group and lung benign disease group,detected the expression of Survivin-mRNA by reverse transcription polymerase chain reaction.Results: Expression of Survivin-mRNA in 46 cases of lung cancer was significantly higher than that of 17 cases of lung benign disease(P<0.05);the expression of Survivin-mRNA had no relation with age,sex and organization type(P>0.05);the expression of poorly differentiated NSCLC was higher than that of well-moderately differentiated NSCLC(P<0.05);the expression of Ⅲ+Ⅳ NSCLC was higher than Ⅰ+Ⅱ NSCLC(P<0.05);there was no difference between the local SCLC and the extensive SCLC(P>0.05).Conclusion: There was value in lung cancer diagnosis,judgment of cancer malignant degree and prognosis assessment by detecting Survivin-mRNA expression in bronchofiberscope biopsy samples. |
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| Keywords: | lung neoplasms Survivin mRNA bronchoscopy biopsy |
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