肿瘤干细胞标记物CD133在鼻咽癌组织中的表达及其临床意义

目的:研究干细胞标记物CD133在鼻咽癌及其声带息肉中的表达及其临床意义.方法:纤维鼻咽镜取30例鼻咽癌组织和10例声带息肉.Trizol法提取的总RNA进行逆转录,实时荧光定量PCR检测组织中CD133的表达.并对鼻咽癌病人予诱导时间调节化疗+同步放、化疗进行治疗.用SPSS 13.0医学统计学软件对结果和疗效进行分析.结果:鼻咽癌组织中CD133表达高于声带息肉组织(P＜0.05),CD133在鼻咽癌组织中的表达与年龄、性别、病理分型以及疗效之间均无统计学关联.结论:CD133在鼻咽癌组织中明显阳性表达,与年龄、性别、病理学类型及疗效之间的联系,还需进一步扩大病例数加以研究.

Expression and clinical significance of cancer stem cells marker CD133 in nasopharyngeal carcinoma

Objective:To investigate the expressions and clinical significance of cancer stem cell marker CD133 in nasopharyngeal carcinoma cells and vocal cord polyp.Methods: Nasopharyngoscope get through the fiber 30 cases of nasopharyngeal carcinoma and 10 cases of vocal cord polyp,CD44 in total RNA extracted by Trizol were detected by SYBR real-time fluorescence quantitative PCR.Nasopharyngeal carcinoma patients receive induced chemotherapy and radiotherapy and chemotherapy treatment.Results: CD133 expressed in nasopharyngeal carcinoma and vocal cord polyp tissue,moreover,the expression of CD133 in nasopharyngeal carcinoma was higher than that of vocal cord polyp(P<0.05).But,there was no relation between the CD133 expression and age,gender,pathological type and short-term efficacy.Conclusion: CD133 was positively expressed in the tissue of nasopharyngeal carcinoma,the correlation between CD133 and age,gender,pathological type as well as therapeutic efficacy will be studied by more cases.