中国维汉族妇女宫颈病变中Survivin的表达及对比研究

目的:探究凋亡抑制蛋白Survivin与宫颈癌发生、发展的关系,对比Survivin的表达在维、汉族之间是否存在族群间差异。方法:收集维吾尔族和汉族妇女宫颈炎(各30例)、宫颈低级别上皮内瘤变(CINⅠ各30例)、高级别上皮内瘤变(CINⅡ-Ⅲ各30例)及宫颈浸润性鳞癌(各30例)石蜡包埋组织标本共240例,采用免疫组织化学SP法。结果:Survivin蛋白的阳性表达定位于细胞质和(或)胞核内,表达强度随病变程度加重呈递增趋势,但CINⅡ-Ⅲ组与宫颈癌组的阳性率无差异(P>0.05),维汉组间比较差异无统计学意义(P>0.05)。结论:Survivin的表达在维、汉族之间不存在族群差异;Survivin蛋白的异常表达与宫颈癌及癌前病变密切相关,实验证实Survivin的过表达出现在恶性转化的早期,促进了宫颈癌的发生发展,Survivin可能成为预测病情转归的指标及靶向治疗基因。

Expression and comparative research of Survivin between Uygur and Han women in different cervical diseases

Objective:To explore the relationship between expression of apoptosis-inhibited protein Survivin and the pathogensis and progression of cervical cancer,to compare the difference between Uygur and Han women.Methods:To collect 30 cases of chronic cervicitis of each nation,30 cases of low-grade squamous intraepithelial lesion in each nation,30 cases of high-grade cervical squamous intraepithelial neoplasia each nation and 30 cases of invasive cervical cancer each nation and to detect the expression of survivin with immunohistochem technique.Results:The positive position of Survivin protein was inside cell cytoplasm and nuclei.The expression rates of Survivin were increased gradually with cervical disease pathogenesis.The positive rate of Survivin was not correlated with high-grade cervical squamous intraepithelial neoplasia and invasive cervical cancer(P>0.05),and the differences were not correlated between Uygur and Han women(P>0.05).There was no difference of Survivin’s expression between Uygur and Han women.Conclusion:The abnormal expression of Survivin protein was related closely with cervical cancer and pre-cancerous,Survivin appears in the early time of malignant transformation,and it promote the occurrence and development of cervical cancer.Survivin may become a target for prognosis and as a gene for targeting treatment.