晚期食管癌2种化疗方案疗效对比观察

目的:观察DF/TP方案化疗晚期食管癌疗效。方法:按治疗方案将患者分为A、B两组,A组予DF(DDP 20mg/m2,d1-5;5-FU 0.5g/m2,d1-5)化疗,有效者(CR/PR)共3-4个周期,化疗2周期未达PR改用TP方案化疗2周期;B组予TP(TAX 175mg/m2,d1,DDP 30mg/m2,d1、2、3)方案化疗,有效者(CR/PR)共3-4个周期,化疗2周期未达PR改用其他治疗方案。结果:两组有效率相近(P﹥0.05),无显著差异;恶心、呕吐、胆红素、转氨酶毒性无显著差异(P﹥0.05);白细胞与血红蛋白毒性、脱发、神经毒性有显著差异(P<0.05);TP方案对DF方案化疗进展或无效者有效率21.05%;DF方案中位进展期3个月,TP方案中位进展期4个月。结论:TP方案二线使用更有优势。

Two regimens for chemotherapy of advanced esophageal cancer in comparison

Objective:To observe the effect of the chemotherapy with DF or TP regimen for advanced esophageal cancer.Methods:Group A: patients were treated with DF regimen(DDP 20mg/m2 d1-5,5-FU 0.5g/m2 d1-5).Patients who were effective(CR or PR) were treated continued with the treatment for 3 to 4 cycles.Patients who were not effective(PR) after 2 chemotherapy cycles were administered with TP(TAX 175mg/m2,d1,DDP 30mg/m2,d1,2,3) regimen for 2 cycles;Group B: patients were treated with TP regimen(TAX 175mg/m2,d1,DDP 30mg/m2,d1,2,3).Patients who were effective(CR or PR) were continued treatment for 3 to 4 cycles.Patients who were not effective(PR) after 2 chemotherapy cycles were administered with other regimen.Results:The effective rate of the two groups of initial treatment was not different(P>0.05).Incidences of nausea and vomiting and toxicity of bilirubin and transaminase were not different(P>0.05),but the toxicity of leucocyte and hemoglobin and hair and nerve was different(P<0.05).The TP regimen was effective to patients who were worsened or ineffective and their effective rates were 21.05% respectively.Median time to progression was 3 months with DF regimen of initial treatment.Median time to progression was 4 months with TP regimen of initial treatment.Conclusion:There was more advantage in the TP regimen as second-line therapy for advanced esophageal cancer.