分化抑制因子Id-1在卵巢癌中的表达及临床意义

目的:探讨Id-1在人卵巢癌组织中的表达及其与临床病理特征的关系。方法:采用免疫组织化学方法检测Id-1在50例卵巢癌组织中的表达,并分析其与临床病理特征的关系。结果:在卵巢癌组织中Id-1的表达率为80.4%,在交界性卵巢肿瘤表达率为30%,正常卵巢组织的表达率为5%,组间比较差异有统计学意义(P<0.05)。Id-1过表达与卵巢癌组织分化程度及淋巴结转移有关(P<0.05),而与患者年龄、临床分期无关(P>0.05)。结论:Id-1在卵巢癌组织中高表达并与卵巢癌组织分化程度及淋巴结转移有关,在卵巢癌的发生、发展中起重要作用。

The expression and clinical significance of Id -1 in ovarian cancer

Objective:To study the expression of inhibitor of differentiation/DNA binding-1(Id-1) in human ovarian cancer and its relation to clinicopathological characteristics.Methods:To determine the expression of Id-1 in 50 cases of ovarian cancer with immunohistochemical method and analyze its relationship with the clinicopathological characteristics.Results:The expression rates of Id-1 in ovarian cancer,borderline ovarian tumor and normal ovarian tissue were 80.4%,30% and 5%,respectively.There was a statistical significance(P<0.01) between groups.The expression of Id-1 in ovarian cancer was correlated with grade of differentiation and lymph node metastasis(P<0.05),but not correlated with age or clinic stages(P>0.05).Conclusion:The expression of Id-1 in ovarian cancer is high,which is correlated with the degree of histologic differentiation of ovarian cancer and lymph node metastasis and plays an important role in the pathogenesis and development of ovarian cancer.