联合检测肿瘤标志物在胸腔积液中的应用价值

目的:探讨胸腔积液中肿瘤标志物癌胚抗原(CEA)、细胞角蛋白19片断(CYFRA21-1)、神经元特异性烯醇化酶(NSE)检测在胸腔积液诊断中的价值。方法:应用电化学发光法对65例肺癌患者和28例良性对照者的血清和胸腔积液进行检测。结果:肺癌组中血清和胸水肿瘤标志物明显高于对照组(P<0.01);肺癌组胸水三项指标高于血清水平(P<0.01);CEA对肺腺癌,NSE对小细胞肺癌,CYFRA21-1对肺鳞癌的阳性率高于其它单项(P<0.05)。结论:胸腔积液CEA、NSE、CYFRA21-1检测有助于肺癌的诊断。

The value of combined detection of tumor markers in pleural effusion

Objective:To study the value of detecting tumor marker carcinoembronic(CEA),neuron specific enolase(NSE)and sytokeratin fragment 21-1(CYFRA21-1)in pleural effusion.Methods: 65 patients with lung cancer and 28 benign controls were detected in serum and pleural effusion by electrochemiluminescence.Results: In serum and pleural effusion of lung cancer group,the values of tumor marker were significantly higher than that in control group(P<0.01);levels of three indicators in pleural effusion were higher than that in serum(P<0.01);the positive rates of CEA in lung adenocarcinoma,NSE in small cell lung cancer and CYFRA21-1 in lung squamous cell carcinoma were higher than any other individual(P<0.05).Conclusion: Pleural effusion CEA,NSE,CYFRA21-1 detection is helpful for the diagnosis of lung cancer