Guineensine, an Acyl-CoA: cholesterol acyltransferase inhibitor, from the fruits of Piper longum |
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| Authors: | Lee Seung Woong Rho Mun-Chual Nam Jung Yeon Lim Eun Hee Kwon Oh Eok Kim Young Ho Lee Hyun Sun Kim Young Kook |
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| Affiliation: | Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, 52 Oun-dong, Yusong-gu, Taejon 305-333, Korea. |
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| Abstract: | Bioactivity-guided fractionations for ACAT inhibitor led to the isolation of guineensine from the CHCl (3) extract of Piper longum. Its structure was identified by spectroscopic means (IR, UV, MS and NMR). Guineensine inhibited ACAT activity in a dose-dependent manner with an IC (50) value of 3.12 micro M. |
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