Triterpenes from Tripterygium wilfordii Hook |
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Authors: | Yang J-H Luo S-D Wang Y-S Zhao J-F Zhang H-B Li L |
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Affiliation: | a School of Pharmacy, Center for Advanced Studies of Medicinal and Organic Chemistry, Yunnan University, Kunming,Yunnan, Chinab State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Kunming, Yunnan, China |
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Abstract: | Two new friedelane-type triterpenes, tripterfrielanons A (1) and B (2), along with six known triterpenoids, friedelin (3), canophyllal (4), canophyllalic acid (5), 3-oxo-29-hydroxyfriedelane (6), wilforlide A (7), wilforlide B (8), have been isolated from the EtOH extract of the roots of Tripterygium wilfordii Hook.f. Compounds 4, 5, 6 were isolated for the first time from this plant. The new triterpenes 1 and 2 exhibited mild cytotoxic activity against human Hela cell lines in vitro. The assay showed the IC50 of 1 and 2 were 8.5 and 25 μg/mL, respectively. |
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Keywords: | Tripterygium wilfordii Hook.f. Celastraceae Triterpenes Tripterfrielanons A-B |
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