Triterpenes from Tripterygium wilfordii Hook |
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| Authors: | Yang J-H Luo S-D Wang Y-S Zhao J-F Zhang H-B Li L |
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| Institution: |
a School of Pharmacy, Center for Advanced Studies of Medicinal and Organic Chemistry, Yunnan University, Kunming,Yunnan, China
b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Kunming, Yunnan, China |
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| Abstract: | Two new friedelane-type triterpenes, tripterfrielanons A (1) and B (2), along with six known triterpenoids, friedelin (3), canophyllal (4), canophyllalic acid (5), 3-oxo-29-hydroxyfriedelane (6), wilforlide A (7), wilforlide B (8), have been isolated from the EtOH extract of the roots of Tripterygium wilfordii Hook.f. Compounds 4, 5, 6 were isolated for the first time from this plant. The new triterpenes 1 and 2 exhibited mild cytotoxic activity against human Hela cell lines in vitro. The assay showed the IC50 of 1 and 2 were 8.5 and 25 μg/mL, respectively. |
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| Keywords: | Tripterygium wilfordii Hook f Celastraceae Triterpenes Tripterfrielanons A-B |
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