Recurrent Epstein–Barr virus associated disease in a cardiac transplant patient: evolution from plasmacytic hyperplasia to diffuse large cell lymphoma |
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| Authors: | L.M. Larratt M. Hamilton R. Coupland J.K. Preiksaitis |
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| Affiliation: | Department of Medicine, University of Alberta, Edmonton, Alberta, Canada;, Department of Pathology, Cross Cancer Institute, Edmonton, Alberta, Canada |
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| Abstract: | Abstract: An Epstein–Barr virus (EBV)-seronegative 31-year-old male underwent cardiac transplantation in 1991 for congenital cardiomyopathy. He presented with a protracted course of waxing and waning lymphadenopathy beginning four years after transplantation with eventual progression to a fulminant EBV-positive large cell lymphoma eight years after transplantation. Risk factors for the development of post-transplant lymphoproliferative disease in this patient, the importance of a standardized approach to pathology in assessing therapeutic options, and the management strategies used are discussed. |
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| Keywords: | Epstein–Barr virus (EBV) large cell lymphoma cardiac transplant post-transplant lymphoproliferative disease cytomegalovirus (CMV) |
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