缬沙坦对高脂血症动脉粥样硬化模型大鼠炎性因子的影响

目的观察缬沙坦对炎性因子水平的影响,探讨其对高脂血症模型大鼠动脉粥样硬化的影响。方法选取30只雄性健康Wistar大鼠,适应性喂养1周后,随机分为3组：正常对照组10只,高脂模型组10只和缬沙坦干预组10只。通过建立高脂血症动脉粥样硬化大鼠模型,动态、系统地监测TNF-α、IL-6和IL-8的水平。结果高脂模型组血清TNF-α、IL-6、IL-8水平均较正常对照组升高,且比较差异具有统计学意义（P〈0.05）。应用缬沙坦治疗10周后,缬沙坦干预组IL-6的水平较高脂模型组降低,比较差异有统计学意义（P〈0.05）;TNF-α和IL-8水平较高脂模型组降低,但比较差异无统计学意义（P〉0.05）。结论缬沙坦能够有效地降压的同时,能减少部分炎性因子释放,发挥其抗动脉粥样硬化的作用。

Effects of valsartan on inflammatory factor in rats hyperlipidemia athrosclerosis model

Objective To study the effects of valsartan on athrosclerosis in rats hyperlipidemia mode, and explore the influence of the level of inflammatory factor. Methods Thirty male health Wistar rats were selected, and feeded adaptability, and randomly divided into three groups: normal control group, high fat model group, and losartan intervention group after a week. The levels of serum lipids TNF-α, IL-6, IL-8 of the hyperlipidemia and atherosclerosis model rats were monitored dynamically and systematically before and after the intervention of valsartan. Results Serum TNF-α, IL-6 and IL-8 in hyperlipaemia group was significantly higher than that of normal group (P < 0.05). The expression of IL-6 in valsartan group were lower than that of hyperlipaemia group, there was significant difference among valsartan group and hyperlipaemia group (P < 0.05). The expression of TNF-α and IL-8 in valsartan group were lower than that of hyperlipaemia group, but there was no significant difference (P > 0.05). Conclusion While valsartan can effectively lower blood pressure, and can play the anti-atherosclerotic effect by reducing some inflammatory cytokine.