| 类风湿性关节炎病因学概述 |
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| 引用本文： | 蔡文虹,孙保东,张宝凤,岳野,成文翔,虎义平,张鹏.类风湿性关节炎病因学概述[J].中国当代医药,2012(5):11-12. |
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| 作者姓名： | 蔡文虹 孙保东 张宝凤 岳野 成文翔 虎义平 张鹏 |
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| 作者单位： | 深圳市人民医院风湿科;深圳市人民医院营养科;中国科学院深圳先进技术研究院医工所医学转化研究与发展中心 |
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| 基金项目： | 国家自然科学基金项目(81000786);广东省深圳市科技立项项目(201103348) |
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| 摘 要： | 类风湿性关节炎（rheumatoid arthritis,RA）是一种常见的慢性、全身性自身免疫疾病,病因复杂多样,就目前所知,归纳起来有遗传因素、微生物感染、激素刺激、吸烟、饮食、寒冷等。其中,遗传因素决定了人体对于疾病的易感性,而微生物感染被认为是类风湿性关节炎的始动阶段。因至今类风湿性关节炎仍无有效治疗方法,对其病因学研究的深入有望为类风湿性关节炎治疗开辟新的前景。
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| 关 键 词： | 类风湿性关节炎 遗传因素 微生物感染 激素 |
Overview of the etiology of rheumatoid arthritis |
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| Authors: | CAI Wenhong SUN Baodong ZHANG Baofeng YUE Ye CHENG Wenxiang HU Yiping ZHANG Peng |
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| Institution: | 1.Department of Rheumatology, Shenzhen People’s Hospital in Guangdong Province, Shenzhen 518020, China; 2.Department of Nutrition, Shenzhen People’s Hospital in Guangdong Province, Shenzhen 518020, China; 3.Center for Translational Medicine R&D, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Guangdong Province, Shenzhen 518055, China |
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| Abstract: | Rheumatoid arthritis is a common chronic, systemic autoimmune disease. The cause of RA is complex and diverse, presently known including genetic factors, microbial infection, hormonal stimulation, smoking, diet, cold and other factors. Among them, genetic factors determine human susceptibility to disease and microbial infection is considered to be the initiating stage of rheumatoid arthritis. As yet no effective treatment to rheumatoid arthritis arising, in-depth study of the etiology is needed to open up a new foreground. |
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| Keywords: | Rheumatoid arthritis Genetic factors Microbial infection Hormone |
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