胺碘酮注射液治疗冠心病室性心律失常

目的探讨胺碘酮治疗冠心病室性心律失常的临床疗效。方法对2009年4月～2011年6月本院门诊及住院确诊的冠心病室性心律失常患者46例，随机分为实验组和对照组各23例。人院后均接受积极的抗心律失常治疗。在接受胺碘酮治疗前1个月，未使用其他抗心律失常药物。实验组给予胺碘酮注射液200mg／次．3次，d，连服1周，然后改为200mg／次，2次，d，连服1周，以后200mg／次，1次，d，以后根据患者病情逐渐减量；对照组口服普罗帕酮150mg／次，3次／d。两组患者均维持治疗2个月，对比两组的临床治疗效果。结果实验组23例患者中。显效12例，有效9例，无效2例，总有效21例，总有效率为90．30％；对照组23例患者中，显效8例，有效7例，无效8例。总有效15例，总有效率为65．22％；两组总有效率比较，差异有统计学意义（P〈0．05）。未出现严重不良反应。结论胺碘酮治疗冠心病室性心律失常疗效显著，安全可靠。但在临床使用时要严格按照适应证。避免不良反应的发生。

Amiodarone injection therapy of ventricular arrhythmias with coronary heart disease

Objective To investigate the clinical efficacy of amiodarone in the treatment of ventricular arrhythmias with coronary heart disease. Methods Forty six cases of inpatient diagnosis of ventricular arrhythmias with coronary heart disease from April 2009 to June 2011 in our hospital were randomly divided into experimental group and control group 23 cases in each. Admission received active antiarrhythmic therapy, 1 month before receiving amiodarone treatment, without the use of other antiarrhythmic drugs. Experimental group was given amiodarone injection of 200 mg/time, 3 times/d, even for a week, then changed to 200 mg/time, 2 times/d, even for a week, after the 200 mg/time, 1 time/d, after the reduction under the patient’s condition gradually; the control group was treated with propafenone 150 mg/time, 3 times/d. All patients received maintenance therapy for two months, compared two groups of clinical treatment. Results The experimental group of 23 patients, 12 cases were markedly effective, 9 cases were effective, 2 cases were not effective, the total number of valid cases in 21 cases, total effective rate was 90.30%; the control group of 23 patients, 8 cases were markedly effective, 7 cases were effective, 8 cases were not effective, the total number of valid cases in 15 cases, total effective rate was 65.22%, there was statistically difference between the two groups (P<0.05). There were no serious adverse reactions. Conclusion Treatment of coronary heart disease with ventricular arrhythmias amiodarone effect is significant, safe and reliable. However, the clinical use must be strictly in accordance with indications to avoid the occurrence of adverse reactions.