美托洛尔对室性心律失常伴心室晚电位阳性作用的临床研究

４６例心室晚电位（ＶＬＰ）阳性的室性心律失常（ＶＡ）患者应用美托洛尔（５０～１００ｍｇ／日）治疗，３８例心律失常得到控制，３９例ＶＬＰ转为阴性。２１例停用美托洛尔后１５例再现ＶＡ，１３例ＶＬＰ恢复阳性。复用美托洛尔仍可控制ＶＡ，并使ＶＬＰ再转为阴性。本研究结果提示：美托洛尔对多数患者可使ＶＡ控制，并能消除ＶＬＰ，每日５０～１００ｍｇ量。效关系不明显，亦无明显副作用，作为抗心律失常药可长期应用。

CLINICAL RESEARCH OF METOPROLOL ON PATIENTS OF VENTRICULAR ARRHYTHMIAS WITH POSITIVE OF VENTRICULAR LATE POTENTIAL

patients of ventricular arrhythmias with positive of ventricular late poten-tial were treated by metoprolol,50～100 mg per day.Ventricular arrhythmia were controledin 38 patients,ventricular late potential were changedd to negative in 39 patients,In all 21 pa-tients wmch stopped oral metoprolol automatically, 15 patients came back the ventricular ar-rhthmia,ventricular late potential return positive in 13 patients. After using metoprolol a-gain, ventricular arrhythmias were controled well ,the ventricular late potential turn in to ne-gartive. This study suggested : metoprolol is able to controle ventricular arrythmias well forthe most patients with arrythmias,and change positive of ventricular late potential to nega-tive,there is no dose-effect relationship between 50～100 mg/d.We did not find obvious sideeffect in this study. metoprolol,as a antiarrhythmia drug,can be used for a long time.