Structural aspects of experimental carbon disulfide neuropathy

Summary In white rats exposed to CS₂ vapors (at the average concentration of 1.5 mg per liter of air) over 1 to 15 months, the progressive development of structural lesions was studied in the selected areas of the central and peripheral nervous system. Gradual destruction of myelinated fibers within the white matter of spinal cord and in the peripheral nerves was observed. Morphological alterations of the body of the nerve cells were also encountered, but their pathologic nature and their relation to the exposure were disputable even at the stage of advanced CS₂ induced myelo- and neuropathy.This investigation has been done under the Polish-American agreement No. 05-003-3 with the Occupational Health Program, U.S. Public Health Service.