| 8—MOP与ATRA联合应用对Mc3细胞bcl—2和P~(53)表达的影响 |
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| 引用本文： | 闫晓光,周训银,吴军正,陈建元,吴红.8—MOP与ATRA联合应用对Mc3细胞bcl—2和P~(53)表达的影响[J].西南国防医药,1999(6). |
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| 作者姓名： | 闫晓光 周训银 吴军正 陈建元 吴红 |
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| 作者单位： | 成都军区昆明总医院口腔科，成都军区昆明总医院口腔科，第四军医大学口腔医学院口腔生物学教研室，第四军医大学口腔医学院口腔生物学教研室，成都军区昆明总医院口腔科 昆明 650032，昆明 650032，昆明 650032 |
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| 摘 要： | 目的:研究8—MOP、ATRA以及二者联合应用对Mc3细胞bcl-2和P~(53)表达的影响。方法:免疫组织化学染色方法。结果:bcl—2表达分别为:对照组( );8-MOP组( );ATRA(-);8—MOP与ATRA联合用药组( );P~(53)表达分别为:对照组( );8-MOP组( );ATRA( );8—MOP与ATRA联合用药组( )。结论:①ATRA处理组细胞bcl—2的阳性表达明显下降,可能导致Mc3细胞发生凋亡;②P~(53)的表达无明显变化。
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| 关 键 词： | 8—甲氧基补骨脂素 全反式维甲酸 粘液表皮样癌 bcl—2 P~(53) |
EFFECTS OF 8 - MOP COMBINED WITH ATRA OR ALONE ON bcl - 2 AND P~(53) EXPRESSION IN Mc 3 CELLS |
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| Yan Xiaoguang,Zhou Xunyin,Wu Junzheng,Chen Jianyuan,Wu Hong.EFFECTS OF 8 - MOP COMBINED WITH ATRA OR ALONE ON bcl - 2 AND P~(53) EXPRESSION IN Mc 3 CELLS[J].Medical Journal of National Defending forces in Southwest China,1999(6). |
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| Authors: | Yan Xiaoguang Zhou Xunyin Wu Junzheng Chen Jianyuan Wu Hong |
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| Institution: | Yan Xiaoguang,Zhou Xunyin,Wu Junzheng,Chen Jianyuan,Wu Hong
Department of Stomatology,Kunming General Hospital of Chengdu Military Command,Kunming,650032. |
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| Abstract: | Objective: To study effects of 8 -methoxypsoralen (8 -MOP) combined with all trans retinoic acid (ATRA) or alone on bcl -2 andP53 expression in Mc3 cells. Method: Cell immunohistochemical staining method. Result: bcl -2 could express in controal group, 8 -MOP group and combined group, but could not express in A-TRA group. P53 could express in all ofthe four groups. Conclusion; ATRA maybe decrease the bcl -2 expression and induce the apptosis of Mc3 cells, but the expression of P53 is not effected by both agents. |
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| Keywords: | 8-methoxypsoralen all trans ectinoic acid bcl-2 P53 gene expression |
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