Visna DNA synthesis and the tempo of infection in vitro |
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| Authors: | A T Haase L Stowring J D Harris B Traynor P Ventura R Peluso M Brahic |
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| Affiliation: | 1. Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA;2. Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA;3. Sidney Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA;4. Department of Medicine (Infectious Diseases), Brigham and Women''s Hospital, Boston, Massachusetts 02115, USA |
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| Abstract: | We have examined the effect of reovirus infection on the CV-1 cytoskeleton. Reovirus infection produces a major disruption of vimentin filaments without producing a discernable disorganization of microtubules or microfilament bundles in CV-1 cells. In addition to disrupting the organization of vimentin filaments, reovirus infection appears to cause a reorganization of vimentin filaments. Viral inclusions contain vimentin filamentous structures. Viral infection also alters the cytoplasmic distribution of mitochondria, consistent with the proposed role of vimentin filaments in determining the distribution of mitochondria. |
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| Keywords: | To whom reprint requests should be addressed. |
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