Effect of continual light deprivation and alpha-2u-globulin replacement therapy on serum concentration of gonadotropins and testicular activity in rats |
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Authors: | P. K. Ghosh R. Biswas H. Mandal and Dr N. M. Biswas |
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Affiliation: | Department of Physiology, University Colleges of Science and Technology, Calcutta 700009, India;Ohio State University, Department of Surgery, Division of Urology, Columbus, Ohio 43229, USA |
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Abstract: | Summary. Prolonged darkness caused a fall in testicular 17 β-hydroxysteroid dehydrogenase (17β-HSD) activity and diminished spermatogenesis, serum levels of gonadotropins, testosterone and α2u-globulin. Administration of α2u-globulin at a dose of 1.5 mg rat−1 per day for 7 days after 68 days of light deprivation, reversed the 17β-HSD activity and serum levels of gonadotropins, testosterone and α2u-globulin, while spermatogenesis was restored to normal. The animals kept in prolonged darkness for 68 days and then received saline (7 days in light-dark cycle, 14 L: 10 D), showed no significant changes of testicular activity, serum levels of gonadotropins, testosterone and α2u-globulin, when compared with dark-exposed animals (68 days) receiving rabbit serum (7 days in light-dark cycle, 14 L: 10 D). These results suggest that α2u-globulin plays an important role in testicular function in dark-exposed rats by inducing gonadotropins and testosterone secretion. |
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Keywords: | Dark exposure α2u-globulin testis gonadotropins testosterone |
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