HLA-DRB1，DQA1，DQB1基因单倍型与华东地区汉族人群白癜风的相关性

目的 探讨HLA-DRB1、DQA1、DQB1基因单倍型与华东地区汉族人群白癜风的相关性。方法 采用聚合酶链反应-序列特异性寡核苷酸探针(PCR-SSOP)方法检测华东地区汉族白癜风患者HLA-DRB1、DQA1、DQB1位点的等位基因,运用遗传学群体与家系资料计算机分析系统3.0筛选并分析单倍型。结果 与正常人对照组比较,HLA-DRB1^*09-DQA1^*03-DQB1^*0303单倍型频率显著增高(Pc=0.02,OR=2.542)。结论 在华东地区汉族人群中,HLA-DRB1^*09-DQA1^*03-DQB1^*0303单倍型可能是白癜风的易感单倍型。

Association of HLA-DRB1, DQA1, DQB1 haplotypes with vitiligo in a Han population in East China

Objective To investigate the association of HLA-DRB1,DQA1,DQB1 haplotypes with vitiligo in a Han popultion in East China.Methods Ninety-eight patients with vitiligo and 150 healthy controls were studied for HLA-DRB1,DQA1 and DQB1 alleles by PCR-sequence specific oligonucleotide probes(SSOP)typing.Then,population and pedigree analysis programs(PPAP 3.0)was used to screen and analyze haplotypes.Results The frequency of the haplotype HLA-DRB1^*09-DQA1^*03-DQB1^*0303 was signifi-cantly higher(Pc=0.02,OR=2.542)in the vitiligo patients than in the controls.Conclusions Our results suggest that a correlation exists between HLA-DRB1,DQA1,DQB1 haplotypes and vitiligo,and HLA-DRB1^*09-DQA1^*03-DQB1^*0303 may be a susceptible haplotype for vitiligo in the Han population in East China.