Marked elevation of CA19-9 in a patient with idiopathic pulmonary fibrosis: CA19-9 as a bad prognostic factor |
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| Authors: | Jiro FUJITA Yuka OBAYASHI Ichiro YAMADORI Yuji OHTSUKI Hiroshi MIYAWAKI Satoko HOJO Yoko FURUKAWA Jiro TAKAHARA |
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| Affiliation: | First Department of Internal Medicine, Kagawa Medical University, Kagawa;Department of Pathology, Okayama University, Okayama;Second Department of Pathology, Kochi Medical School, Kochi, Japan |
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| Abstract: | Abstract A 53-year-old Japanese female, who had been suffering from idiopathic pulmonary fibrosis (IPF) for 3 years, was admitted with dyspnoea. The important laboratory finding on admission was a serum CA19-9 level of 649 U/mL. Despite steroid treatment for IPF, her respiratory condition gradually deteriorated with the increase of serum CA19-9 level up to 3020 U/mL and she died of respiratory failure. Immunohistochemistry showed the positive stain of CA19-9 in bronchoepithelial cells. We also reviewed the Index Medics and picked up the cases who had elevation of CA19-9 more than 1000 U/mL, and six patients were listed. Five of these six patients died within 6 months, therefore the marked elevation of CA19-9 seemed to be a bad prognostic factor in patients with pulmonary fibrosis. |
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| Keywords: | bad prognosis CA19-9 idiopathic pulmonary fibrosis |
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