Concurrent gastrinoma and somatostatinoma in a 10-year-old Portuguese water dog |
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Authors: | Hoenerhoff M Kiupel M |
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Institution: | Department of Pathobiology and Diagnostic Investigations, Diagnostic Center for Population and Animal Health, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48823, USA. |
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Abstract: | Severe hypergastrinaemia in the dog is considered a strong indicator for a gastrin-producing pancreatic islet cell tumour. In human medicine, gastrinomas are described as enteropancreatic neuroendocrine tumours that cause the Zollinger-Ellison syndrome. However, in contrast to the supposed origin of canine gastrinomas in pancreatic islets, gastrinomas in human beings arise predominantly in the duodenum and gastric antrum, and are often a component of the syndrome of multiple endocrine neoplasia type I. This report is of a canine case of multiple endocrine neoplasms, consisting of a pancreatic islet cell somatostatinoma, and a gastrinoma in the mesenteric lymph nodes and liver. From the literature and the authors' findings, it is concluded that the clinical diagnosis of hypergastrinaemia is not pathognomonic for a gastrin-producing islet cell tumour. Furthermore, the presence of an islet cell tumour in the face of hypergastrinaemia does not warrant a diagnosis of an islet cell gastrinoma. Immunohistochemistry is necessary to confirm the diagnosis of a pancreatic islet cell gastrinoma. |
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Keywords: | dog gastrinoma man multiple endocrine neoplasia somatostatinoma tumour Zollinger-Ellison syndrome |
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