| 原癌基因c-fos及c-jun在银屑病皮损中的异常表达 |
| |
| 引用本文： | 刘娟 王剑波. 原癌基因c-fos及c-jun在银屑病皮损中的异常表达[J]. 中国皮肤性病学杂志, 1999, 13(1): 13-14 |
| |
| 作者姓名： | 刘娟 王剑波 |
| |
| 作者单位： | [1]西安医科大学第二临床医学院皮肤科 [2]第四军医大学西京医院病理科 |
| |
| 摘 要： | 目的为了探索ｃ ｆｏｓ、ｃ ｊｕｎ与银屑病的关系。方法运用原位杂交技术并通过图像定量分析，对３６例寻常性银屑病患者及１５例正常人皮肤中ｃ ｆｏｓ及ｃ ｊｕｎ的表达进行观察。结果银屑病进行期皮损中，ｃ ｆｏｓ、ｃ ｊｕｎ表达全层减少（Ｐ＜０．０１），恢复期皮损中ｃ ｆｏｓ、ｃ ｊｕｎ的表达与正常皮肤差异无显著性意义Ｐ＞０．０５）。结论提示ｃ ｆｏｓ、ｃ ｊｕｎ可能与银屑病角朊细胞分化受阻及表现型异常密切有关。
|
| 关 键 词： | 原癌基因蛋白质c-fos类 原癌基因蛋白质c-jun类 银屑病 |
The Expression of c fos and c jun Protooncogenes in Psoriatic Lesion. |
| |
| Liu Juan,Feng Jie,Wang Jianbo. The Expression of c fos and c jun Protooncogenes in Psoriatic Lesion.[J]. The Chinese Journal of Dermatovenereology, 1999, 13(1): 13-14 |
| |
| Authors: | Liu Juan Feng Jie Wang Jianbo |
| |
| Affiliation: | Liu Juan,Feng Jie,Wang Jianbo.Department of Dermatology,Second Affiliated Hospital,Xi'an Medical University,Xi'an,710004 |
| |
| Abstract: | Objective To explore the role of c fos and c jun expression in psoriasis.Methods By means of in situ hybridization and image quantitative analysis,we observed the expression of c fos and c jun in thirty six cases of psoriasis vulgaris and fifteen normal controls.Results The expression of c fos and c jun in psoriatic lesions was signifiicantly decreased throughout the epidermal layers in cases of progressive phase comparing with those in normal skin( P <0.01);the expression of c fos and c jun in the lesions of recovery phase had no marked difference to those in normal skin( P >0.05).Conclusion c fos and c jun may be highly related to the expression blockage of differentiation and phenotype of psoriatic keratinocytes. |
| |
| Keywords: | Proto oncogenes proteins c fos Proto oncogenes proteins c jun Psoriasis |
| 本文献已被 CNKI 维普 等数据库收录！ |
