Ochronosis of the aortic valve and aorta |
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Authors: | Kovacevic Miljenko Simic Ognjen Medved Igor Lucin Ksenija Padovan Marijan |
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Affiliation: | Department of Cardiac Surgery, University Hospital Rijeka, Croatia. m.kovacevic@inet.hr |
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Abstract: | A 64-year-old male patient with unknown alkaptonuria and severe aortic stenosis and ischemic heart disease was admitted to the authors' institution for elective surgery. The patient underwent aortic valve replacement with a 25-mm aortic valve (ATS Medical, Inc.) and single venous aortocoronary artery bypass grafting for a right coronary artery. Aortotomy revealed typical ochronotic pigmentation of a severely calcified aortic valve and aortic intima. A diagnosis of alkaptonuria was confirmed by evidence of homogentisic acid in the patient's urine, together with histopathological analysis. |
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