| 莱菔子行气消食的机制研究 |
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| 引用本文： | 唐健元,张磊,彭成,刘友平,马莉. 莱菔子行气消食的机制研究[J]. 中国中西医结合消化杂志, 2003, 11(5): 287-289 |
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| 作者姓名： | 唐健元 张磊 彭成 刘友平 马莉 |
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| 作者单位： | 1. 成都中医药大学,成都,610075
2. 国家药品监督管理局药品审评中心,北京,100038 |
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| 摘 要： | 目的 :研究莱菔子行气消食的作用机制。方法 :观察莱菔子促进胃肠运动的活性部位对小鼠排空液体和固体、对阿托品和多巴胺所造成的小鼠胃肠运动抑制以及大鼠血浆胃动素 (MTL )水平的影响 ,并与西沙比利对照。结果 :莱菔子促进胃肠运动的活性部位能增加大鼠血浆 MTL的含量 ,但可被阿托品所拮抗。与阳性对照药西沙比利比较差异无显著性意义 (P >0 .0 5 )。结论 :莱菔子行气消食的作用机制可能与促进 MTL的分泌和作用于 M受体有关。
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| 关 键 词： | 莱菔子 行气消食 作用机制 MTL 胃肠运动 胃肠激索 正己烷提取物 |
Study on Mechanism of Semen Raphani in Moving qi and Removing Food Retention |
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| TANG Jianyuan,ZHANG Lei,PENG Cheng,et al Chengdu University of TCM,Chengdu. Study on Mechanism of Semen Raphani in Moving qi and Removing Food Retention[J]. Chinese Journal of Integrated Traditional and Western Medicine on Digestion, 2003, 11(5): 287-289 |
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| Authors: | TANG Jianyuan ZHANG Lei PENG Cheng et al Chengdu University of TCM Chengdu |
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| Affiliation: | TANG Jianyuan,ZHANG Lei,PENG Cheng,et al Chengdu University of TCM,Chengdu 610075 |
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| Abstract: | Objective:To study the functional mechanism of Semen Raphani which moves qi and removes food retention.Methods:Cisapride was assigned as the positive control group. The effect of the drug on emptying liquid and solid of mice, inhibited gastrointestinal movement induced by Atropine and Dopamine, and the level of MTL in blood was observed.Results:N-hexane part could improve the gastrointestinal movement more than any others. But the effect could be prevented by Atropine. N-hexane part could increase the level of MTL in blood, which was similar to Cisapride (P>0.05).Conclusion:The mechanism of Semen Raphani may be related to increasing the secretion of MTL and affecting the M-receptor. |
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| Keywords: | moving qi and removing food retention gastrointestinal movement Semen Raphani gastrointestinal hormone N-hexane part |
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