| 蛋白酶活化受体的心血管效应 |
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| 引用本文： | 蔡大勇,唐朝枢. 蛋白酶活化受体的心血管效应[J]. 中国心血管病研究杂志, 2005, 3(6): 452-455 |
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| 作者姓名： | 蔡大勇 唐朝枢 |
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| 作者单位： | 北京中医药大学基础部，北京大学医学部病理生理学系 100029北京市 |
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| 基金项目： | 国家重点基础研究发展规划项目(No.G2000056905)资助 |
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| 摘 要： | 蛋白酶活化受体为一类G蛋白偶联受体,氨基末端被丝氨酸蛋白酶水解,新末端能激活受体自身,启动细胞内信号转导。本文综述了该类受体酶解活化在心血管系统中的生理作用和病理生理效应(炎症和修复等)。
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| 关 键 词： | 蛋白酶活化受体 心脏 血管 效应 |
| 文章编号： | 1672-5301(2005)06-0452-04 |
| 修稿时间： | 2005-01-20 |
Cardiovascular roles of protease-activated receptors |
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| Cai Dayong%Tang Chaoshu. Cardiovascular roles of protease-activated receptors[J]. Chinese Journal of Cardiovascular Review, 2005, 3(6): 452-455 |
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| Authors: | Cai Dayong%Tang Chaoshu |
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| Affiliation: | Cai Dayong,Tang Chaoshu Department of basic Medicine,Beijing University of Traditional Chinese Medicine and Pharmacy,Beijing 100029,China |
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| Abstract: | Protease-activated receptors (PARs) comprise a family of G protein-coupled receptors with proteolytic activation mechanism. The amino terminal of PARs are proteolytized by serine proteinases, new amino terminal can activate the PAR itself, then start its intracellular signal transductions. The important roles of PARs in the cardiovascular physiology and the cardiovascular pathophysiology have been summarized in this review. |
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| Keywords: | Protease-Activated receptor Cardiovascular role |
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