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A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation |
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| Authors: | Radulovic D M Karljikovic-Rajic K D Lucic B M Vujic Z B |
| Affiliation: | a Faculty of Pharmacy, Institute of Pharmaceutical Chemistry and Drug Analysis, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Yugoslavia b Faculty of Pharmacy, Institute of Analytical Chemistry, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Yugoslavia |
| Abstract: | The inclusion complex formation between Metoprolol tartarata (MeT) and β-cyclodextrin (β-CD) has been investigated using hyperchromic shift at λmax 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH values 4.0 and 8.0 were established for optimal inclusion complex formation and confirmed two stoichiometric compositions 1:1 and 1:2. Preliminary data on usage of MeT/β-CD complex in reversed-phase HPLC indicate the potential application of this complex as a kind of pre-column derivatization for enantiomeric separation of β1-blockers. |
| Keywords: | Metoprolol tartrate β-Cyclodextrin Inclusion complex UV-spectrophotometry Enantiomeric separation |
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