| 肠内营养对梗阻性黄疸幼鼠肠黏膜Bax、Bcl-2蛋白表达的影响及意义 |
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| 引用本文： | 胡凤爱,张帆,赵冬梅,张璐萍,刘烨辉,傅廷亮. 肠内营养对梗阻性黄疸幼鼠肠黏膜Bax、Bcl-2蛋白表达的影响及意义[J]. 滨州医学院学报, 2009, 32(5): 327-330 |
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| 作者姓名： | 胡凤爱 张帆 赵冬梅 张璐萍 刘烨辉 傅廷亮 |
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| 作者单位： | 1. 滨州医学院解剖学教研室,滨州市,256603
2. 滨州医学院附属医院临床营养中心 |
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| 基金项目： | 滨州医学院科技计划，滨州医学院大学生科技创新活动基金 |
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| 摘 要： | 目的探讨肠内营养对梗阻性黄疸幼鼠肠黏膜中Bax、Bcl-2表达的影响及意义。方法将40只Wistar大鼠随机分为正常对照组、假手术组、梗阻性黄疸（OJ）组、OJ＋能全素组，免疫组织化学法检测肠黏膜Bcl-2和Bax蛋白的表达。结果OJ组大鼠肠黏膜Bcl-2表达降低，Bax表达升高，Bcl-2／Bax比值下降（均P〈0．01）；OJ＋能全素组大鼠Bcl-2表达增加（P〈0．05），Bax表达降低（P〈0．01），Bcl-2／Bax比值升高（P〈0．01）。结论梗阻性黄疸时肠黏膜细胞凋亡显著增加，应用肠内营养对肠黏膜损伤有保护作用，其机制可能是与上调肠黏膜Bcl-2蛋白及下调Bax蛋白有关。
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| 关 键 词： | 梗阻性黄疸 肠内营养 Bax Bcl-2 |
Effects of enteral nutrition on Bax and Bcl-2 expression in gut mucosa in rats with obstructive jaundice and its significance |
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| HU Fengai,ZHANG Fan,ZHAO Dongmei,ZHANG Luping,LIU Yehui,FU Tingliang. Effects of enteral nutrition on Bax and Bcl-2 expression in gut mucosa in rats with obstructive jaundice and its significance[J]. Journal of Binzhou Medical College, 2009, 32(5): 327-330 |
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| Authors: | HU Fengai ZHANG Fan ZHAO Dongmei ZHANG Luping LIU Yehui FU Tingliang |
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| Affiliation: | HU Feng'ai1 ZHANG Fan2 ZHAO Dongmei1 ZHANG Luping1 LIU Yehui1 FU Tingliang21 Department of Anatomy,Binzhou Medical University,Binzhou 256603,2 Clinical Nutrition Center,Affiliated Hospital of Binzhou Medical University |
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| Abstract: | Objective To study the effects of enteral nutrition on expression of Bax and Bcl-2 in gut mucosa in rats with obstructive jaundice.Methods The Wistar rats were randomly divided into normal control group,sham operation group,obstructive jaundice(OJ) group,and obstructive jaundice group with nutrison(OJ+N).The expression of Bax and Bcl-2 in intestinal mucosa was tested by immunohistochemical methods.Results The expression of Bcl-2 in intestinal mucosa in OJ group decreased,while the expression of Bax increase... |
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| Keywords: | Bax Bcl-2 |
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