还原型谷胱甘肽对抗结核治疗所致肝损害的预防作用探讨

目的探讨抗结核药物引起肝损害的机制以及还原型谷胱甘肽的预防作用。方法116例患者随机分成两组,治疗组61例,对照组55例。治疗组在抗结核治疗同时予以还原型谷胱甘肽,而对照组在抗结核治疗同时予以肝太乐治疗。结果对照组肝损害的发生率为2445%,而治疗组仅为163%,差异非常显著(P<0001);肝损害发生后血清过氧化脂质(LPO)水平增高,超氧化物歧化酶活性水平降低,与治疗前及肝功能正常者相比有显著差异(P<005)。结论抗结核药物所引起的肝脏损害与体内的脂质过氧化有关,且其可消耗体内的抗氧化物质。应用还原型谷胱甘肽能显著降低肝损害的发生。

The Mechanism of Hepatic Lesion Caused by Antituberculosis Drugs and Prophylactic Effect of Reduced Glutathione

OBJECTIVE:To study the mechanism of hepatic lesion caused by antituberculosis drugs and prophylactic effect of reduced glutathione. METHODS: 116 patients were randomly divided into two groups, treatment group (61 cases) was given reduced glutathione and control group (55 cases) was given glucurolactone. RESULTS:The incidence of hepatic lesion in control group was 24 45%, but in treatment group was only 1 63%. There was a significant difference between these two groups( P <0 001). The serum level of lipid peroxides (LPO) in patients with hepatic lesion was significantly higher but the level of super oxide dismutase (SOD) activity was low. There was a great difference compared with that before treatment and in the patients with normal liver function( P <0 05).CONCLUSION:Hepatic lesion caused by antituberculosis drugs was related with peroxide of lipid, which can consume anti-oxides of the body. The use of reduced glutathione could obviously lower the occurrence of hepatic lesion caused by antituberculosis drugs.