结直肠癌肝转移患者的预后因素分析

目的：分析结直肠癌伴肝转移患者手术切除后影响术后生存率的危险因素。方法：回顾性分析54例手术治疗的结直肠癌肝转移患者的临床及随访资料，对相关因素行单因素和多因素分析。结果：单因素分析显示，原发癌分化程度、淋巴转移、肝转移灶数目、肝转移灶肿瘤大小、手术方式及是否术后进行综合治疗等为影响患者预后的因素（均P<0.05）；多因素分析表明，手术方式、淋巴结转移和原发肿瘤分化程度是主要危险因素（均P<0.05）。结论：及早发现并进行根治切除以及加强术后综合治疗是提高本病远期疗效的关键。

Analysis of prognostic factors for colorectal cancer patients with liver metastases

Objective: To determine the risk factors affecting the survival of patients with colorectal cancer liver metastases after surgical resection. Methods: The clinical and follow-up data of 54 patients with colorectal cancer liver metastases undergoing surgical treatment were reviewed. The associated factors were examined by univariate and multivariate analyses. Results: The univariate analysis showed that the degree of differentiation of the primary tumor, lymph node metastasis, number and size of the liver metastases, surgical approach and whether the postoperative comprehensive treatment was given were associated with the prognosis of the patients (all P<0.05). The multivariate analysis identified that surgical approach, lymph node metastasis and the degree of differentiation of the primary tumor were the major risk factors (all P<0.05). Conclusion: Early detection and radical resection followed by intensive postoperative treatment are critical to improve long-term outcomes in these patients.