Occupational exposure to hexachlorocyclohexane |
| |
Authors: | J. Angerer R. Maaß R. Heinrich |
| |
Affiliation: | (1) Ordinariat für Arbeitsmedizin der Universität und Zentralinstitut für Arbeitsmedizin der Gesundheitsbehörde der Freien und Hansestadt Hamburg, Adolph-Sch6nfelderstr. 5, D-2000 Hamburg 76, Germany |
| |
Abstract: | Summary Metabolism of -Hexachlorocyclohexane (HCH) was studied examining 21 workers producing this insecticide. Using gas chromatography in combination with ECD and mass spectrometry 14 mono-, di-, tri- and tetrachlorophenols were identified in the urine samples of the workers. Seven dihydroxychlorobenzenes of still unknown configuration were detected by mass spectrometry. Ten of the more abundant metabolites, di-, tri- and tetrachlorophenols were determined quantitatively in all urine samples. 2,4,6-; 2,3,5- and 2,4,5-trichlorophenol turned out to be the main metabolites of -HCH. They were excreted in nearly equal quantities. On account of their potential liver toxicity, the determination of chlorophenols in urine should be part of a biological monitoring program of HCH-exposed persons. |
| |
Keywords: | /content/hu494783607m8429/xxlarge947.gif" alt=" gamma" align=" MIDDLE" BORDER=" 0" >-HCH Metabolism Chlorophenols |
本文献已被 SpringerLink 等数据库收录! |
|