荭草苷的抗血栓作用研究

目的:研究荭草苷的抗血栓作用。方法:观察预防给予荭草苷后对小鼠体外凝血时间、小鼠全血凝块溶解作用、家兔血浆凝血酶原时间(PT)、家兔血浆白陶土部分凝血活酶时间(KPTT)、家兔血浆凝血酶时间(TT)、二磷酸腺苷二钠(ADP)诱导的家兔血小板聚集作用、家兔优球蛋白溶解时间(ELT)的影响。结果:与生理盐水组比较,荭草苷(1、2、4mg/kg)组能显著延长小鼠体外凝血时间,对小鼠全血凝块溶解作用无明显影响;荭草苷(0·625、1·25、2·5mg/kg)组能明显延长家兔PT、KPTT及TT,并能显著抑制ADP引起的血小板聚集,对家兔ELT无明显影响。结论:荭草苷具有明显的抗血栓形成作用。

Antithrombotic Effect of Orientoside

OBJECTIVE:To study the antithrombotic effect of orientoside.METHODS:The effects of prophylactic oriento_side on the clotting time in vitro and the systemic clots dissolution of mice,the plasma prothrombin time(PT),the kaolin partial thromboplastin time(KPTT),the thrombin time(TT),and the platelet aggregation induced by ADP and the euglobulin lysis time (ELT)in rabbits were studied.RESULTS:As compared with the normal saline group,orientoside(1,2,and 4mg/kg)signi_ficantly prolonged the clotting time of mice in vitro,yet which had no significant influence on the systemic clots dissolution of mice;while orientoside(0.625,1.25 and 2.5 mg/kg)significantly prolonged the PT,KPTT and TT of rabbits,and significantly inhibited platelet aggregation of rabbits induced by ADP,yet which had no significant influence on the ELT of the rabbits.CONCLUSION:Orientoside can significantly inhibit the formation of thrombus.