| 碱性成纤维细胞生长因子和丹参对反复高＋Gz暴露致脑损伤保护作用的实验研究 |
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| 引用本文： | 刘红巾,蔡庆,纪桂英,王喆,姜建东,朱美财.碱性成纤维细胞生长因子和丹参对反复高＋Gz暴露致脑损伤保护作用的实验研究[J].航天医学与医学工程,2001,14(2):137-139. |
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| 作者姓名： | 刘红巾 蔡庆 纪桂英 王喆 姜建东 朱美财 |
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| 作者单位： | [1]空军总医院航空病研究中心，北京100036 [2]空军总医院分子生物学研究中心，北京100036 |
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| 基金项目： | 全军医药卫生科研基金课题! ( 98D0 3 3 )，空军后勤部
科研基金课题!(KH99190 76) |
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| 摘 要： | 目的探讨碱性成纤维细胞生长因子(bFGF)和丹参对反复高 Gz暴露致脑损伤的防护作用。方法选用200g左右的SD大鼠，在 Gz暴露前后分别给予腹腔注射bFGF(100μg/kg)或丹参(15μg/kg)各一次，置动物离心机离心后不同时间处死，测定脑组织兴奋性氨基酸(EAAs)及一氧化氮(NO)的含量和凋亡细胞数，并与对照组和生理盐水组的测定值比较。结果 Gz暴露组的EAAs、NO含量和凋亡细胞数明显高于对照组，而bFGF和丹参处理组的测定值明显低于 Gz暴露组和生理盐水处理组。结论bFGF和丹参能降低 Gz暴露后脑内EAAs和NO的含量及凋亡细胞数，对 Gz暴露所致脑损伤具有保护和修复作用。
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| 关 键 词： | 碱性成纤维细胞 生长因子 丹参 正加速度 兴奋性氨基酸 一氧化氮 细胞凋亡 |
Experimental Studies of the Protective Effects of Basic Fibroblast Growth Factor and Radix Salviae Miltiorrhizae on Brain Injury in Rats Caused by Repeated Exposures +Gz |
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| LIU Hong jin,CAI Qing,JI Gui ying,WANG Zhe,JIANG Jian dong,ZHU Mei cai. Address reprint requests to:LIU Hong jin. Clinical Aeromedical Center,General Hospital of Air Force,Beijing ,China.Experimental Studies of the Protective Effects of Basic Fibroblast Growth Factor and Radix Salviae Miltiorrhizae on Brain Injury in Rats Caused by Repeated Exposures +Gz[J].Space Medicine & Medical Engineering,2001,14(2):137-139. |
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| Authors: | LIU Hong jin CAI Qing JI Gui ying WANG Zhe JIANG Jian dong ZHU Mei cai Address reprint requests to:LIU Hong jin Clinical Aeromedical Center General Hospital of Air Force Beijing China |
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| Institution: | LIU Hong jin,CAI Qing,JI Gui ying,WANG Zhe,JIANG Jian dong,ZHU Mei cai. Address reprint requests to:LIU Hong jin. Clinical Aeromedical Center,General Hospital of Air Force,Beijing 100036,China |
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| Abstract: | Objective To investigate the preventive and theralseutive effects of basic fibroblast growth factor (bFGF) and Radix Salviae Miltiorrhizae (RSM) on brain injury caused by repeated +Gz exposures. Method bFGF and RSM were injected intraperitoneally into SD rats before and after repeated +Gz exposures. The contents of excitatory amino acids (EAAs), nitric oxide (NO) and the number of cell apoptosis in the brain were measured,and were compared to those of the control group and normal saline (NS) group. Result The contents of EAAs, NO and the number of cell apoptosis were significantly higher in repeated +Gz exposures group than those in control group. The values were markedly lower in bFGF and RSM group than those in repeated +Gz exposures group and NS group. Conclusion bFGF and RSM showed distinct preventive and therapeutic effect on the brain injury induced by repeated +Gz exposures. |
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| Keywords: | basic fibroblast growth factor Radix Salviae Miltiorrhizae positive acceleration excitatory amino acids nitric oxide apoptosis |
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