肿节风水提物抗放射诱导氧化损伤的临床观察

目的观察肿节风水提物抗氧化损伤的临床疗效。方法选择Ⅲ和Ⅳa期鼻咽癌（NPC）患者46例随机分为对照组和研究组，其中对照组25例，研究组21例。所有患者均采用放化综合治疗的方法，研究组配合单剂中药肿节风水提物20g／d口服。分,NN定治疗前后血浆总超氧化物歧化酶（SOD）活力和丙二醛（MDA）含量，并观察2组治疗后肿瘤消退情况和急性放化疗副反应。结果所有患者均完成治疗后与治疗前比较，对照组血浆总SOD活力降低，血浆MDA含量升高；而研究组二者均降低，治疗后研究组血浆总SOD活力高于对照组，MDA含量显著低于对照组，差异均有统计学意义（P〈0．05）。放疗后两组肿瘤局部控制率无差异（P〉0．05）。研究组的急性放化疗副反应出现的频率和严重度均低于对照组，差异有统计学意义（P〈0．05）。结论肿节风水提物有抗氧化损伤的作用，与放化疗结合治疗可使Ⅲ和Ⅳa期NPC肿瘤消退满意，对放化疗所致的副反应有一定消除作用。

The clinical observation of Sarcandra glabra extracts against oxidative damage induced by radiation

Objective To observe the clinical effect of Sarcandra glabra extracts against oxida-tive damage. Methods 46 patients diagnosed as nasopharyngeal careinoma stage Ⅲ and Ⅳ a were ran-domly divided into control group (n=25) and study group (n=21). All patients underwent combined chemoradiotherapy treatment. Besides, the patients in study group were given Sarcandra glabra 20 g/d orally. The total activity of superoxide dismutase (SOD) and plasma eontent of malonaldehyde (MDA) were measured before and after treatment. The tumor regression and aeute chemoradiotherapy side reaction were observed after treatment. Results All patients fulfilled the whole range treatment, After treatment, the total plasma SOD activity decreased and plasma MDA level was elevated in con-trol group, while both SOD aetivity and MDA level were reduced in study group (P<0. 05). When the therapy ended, the SOD of study group was higher and MDA was lower than that of control group (P<0.05). There was no difference in tumor local control rate after radiotherapy between two groups (P>0.05). The incidence rate and severity of acute chemoradiotherapy side reaction were slighter in study group than those in control group (P<0. 05). Conclusion Sarcandra glabra extracts exerts obvious inhibitory effect on oxidative damage. Combined with chemoradiotherapy, Sarcandra glabra contributes to the tumor regression of patients with stage Ⅲ and Ⅳa nasopharyngeal carcinoma and at-tenuation of chemoradiotherapy side reaction.