病毒性心肌炎患儿血清中性粒细胞激活肽78和血管内皮细胞钙黏蛋白水平的变化

目的 探讨病毒性心肌炎患儿血清中性粒细胞激活肽78 (ENA-78)和血管内皮细胞钙黏蛋白(VE-cadherin)的变化及临床意义.方法 采用酶联免疫-双抗体夹心法测定52例病毒性心肌炎患儿血清ENA-78和VE-cadherin水平,同时检测肌酸激酶同工酶(CK-MB),并与36例健康儿童作对照.结果 病毒性心肌炎患儿急性期血清ENA-78和VE-cadherin水平明显高于恢复期及正常对照组[分别为(146.65±15.62) ng/L比(78.72±13.37) ng/L、(63.75 ±12.14) ng/L,(5.36±0.92))mg/L比(2.93±0.64) mg/L、(2.86±0.65) mg/L,P＜0.01]；恢复期ENA-78和VE-cadherin水平与正常对照组比较,差异无统计学意义(P＞0.05).病毒性心肌炎患儿ENA-78与VE-cadherin、CK-MB呈正相关(r=0.73,0.79,P＜0.05),VE-cadherin 与CK-MB亦呈正相关(r=0.82,P＜0.05).结论 ENA-78和VE-cadherin可能参与病毒性心肌炎的发生、发展,并可作为病情判断及预后的观察指标.

Changes of epithelial neutrophil-activing peptide-78 and vascular endothelial cadherin in serum of children with viral myocarditis

Objective To investigate the changes of epithelial neutrophil-activing peptide-78 (ENA-78)and vascular endothelial cadberin(VE-cadherin.) in serum of children with viral myocarditis and their clinical significance.Methods The serum levels of ENA-78 and VE-cadberin were detected by enzyme-linked immunosorbent assay in 52 children with viral myocarditis,and 36 normal healthy children as controls.Creatine kinase-isoenzyme (CK-MB) was also measured.Results The serum levels of ENA-78,VE-cadherin and CK-MB in viral myocarditis group with the acute stage were higher than those of viral myocarditis group with recovery stage and control group [(146.65 ± 15.62)ng/L vs (78.72 ± 13.37)ng/L vs (63.75 ±12.14) ng/L,(5.36 ±0.92)mg/L vs (2.93 ±0.64) mg/L vs (2.86:± 0.65 ) mg/L,respectively,P ＜ 0.01 ].There was no significant difference in the serum levels of ENA-78,VE-cadherin and CK-MB between viral myocarditis group with the recovery stage and control group (P ＞ 0.05).And there was positive correlation between ENA-78 and VE-cadherin,CK-MB (r =0.73,0.79,P ＜0.05 ) ; there was positive correlation between VE-cadberin and CK-MB ( r =0.82,P ＜ 0.05 ).Conclusion ENA78 and VE-cadherin may play role in the viral myocarditis pathogenesis and can be new prognosis factors for viral myocarditis.