| 多巴胺转运体基因与注意缺损多动障碍 |
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| 引用本文： | 江三多,忻仁娥,钱伊萍,林嗣萃,汤国梅,汪栋祥,陈美娣,任大明.多巴胺转运体基因与注意缺损多动障碍[J].中国神经精神疾病杂志,1999(6). |
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| 作者姓名： | 江三多 忻仁娥 钱伊萍 林嗣萃 汤国梅 汪栋祥 陈美娣 任大明 |
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| 作者单位： | 上海精神卫生中心!200030(江三多，忻仁娥，钱伊萍，林嗣萃，汤国梅，汪栋祥，陈美娣)，复旦大学遗传研究所(任大明) |
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| 摘 要： | 目的 探讨注意缺损多动障碍（ＡＤＨＤ） 与多巴胺转运体（ＤＡＴ１） 基因间的关系。方法 分别采用基于单体型和基于基因型的单体型相对风险分析方法，在上海地区汉族人群中对ＡＤＨＤ 与ＤＡＴ１ 基因微卫星多态性进行遗传关联分析。结果 ①上海地区汉族人中，ＤＡＴ１ 基因多态以４８０ ｂｐ 重复片段为主，其基因频率为９２％ 。②以父母双亲为对照，经ＧＨＲＲ 和ＨＨＲＲ 分析，ＤＡＴ１ 基因与ＡＤＨＤ 均无关联。结论 上海地区汉族人群中ＤＡＴ１ 基因多态与ＡＤＨＤ 无关。
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| 关 键 词： | 注意缺损多动障碍 DAT1基因 基于单体型的单体型相对风险 基于基因型的单体型相对风险 |
The relationship between attention deficit hyperactivity disorder and dopamine transporter 1 gene. |
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| Jiang Sanduo,Xin Rener,Qian Yiping,Lin Sicui,Tang Guomei,Wang Dongyang,Chen Meidi and Ren Daming,Shanghai Mental Health Center,Fudan University Wan Pimg Nan Road,Shanghai. . Tel:--.The relationship between attention deficit hyperactivity disorder and dopamine transporter 1 gene.[J].Chinese Journal of Nervous and Mental Diseases,1999(6). |
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| Authors: | Jiang Sanduo Xin Rener Qian Yiping Lin Sicui Tang Guomei Wang Dongyang Chen Meidi and Ren Daming Shanghai Mental Health Center Fudan University Wan Pimg Nan Road Shanghai Tel:-- |
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| Institution: | Jiang Sanduo,Xin Rener,Qian Yiping,Lin Sicui,Tang Guomei,Wang Dongyang,Chen Meidi and Ren Daming,Shanghai Mental Health Center,Fudan University 600 Wan Pimg Nan Road,Shanghai. 200030. Tel:021-6438-7250 |
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| Abstract: | Objective The present study was designed to investigate the relationship between attention deficit hyperactivity disorder (ADHD) and minisatellite polymorphism of dopamine transporter 1 gene (DAT1 gene) in the Han population in Shanghai. Methods The haplotype based haplotype relative risk (HHRR) and genotype based haplotype relative risk (GHRR) methods were used to analyzed the relationship in 74 ADHD children and their parents. Results In our samples, 10 repeats (480 bp) were the dominant allele of DAT1 minisatellite polymorphisms with the allele frequency 0.92, and we found no significant association between the DAT1 minisatellite polymorphism and ADHD ( P>0.05 ). Conclusions Our results do not support that ADHD is associated with the DAT1 minisatellite polymorphism in the Han population in Shanghai. |
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| Keywords: | ADHD DAT1 gene Haplotype based haplotype relative risk Genotype based haplotype relative risk |
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