Spontaneous amphophilic focus in the liver of a young Sprague-Dawley rat |
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| Authors: | Hiroko Sato Tetsuya Sakairi Shiro Takagi Kazuyuki Kitamura |
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| Institution: | Safety Research Laboratories, Research Division, Mitsubishi Tanabe Pharma Corporation, 1-1-1, Kazusakamatari, Kisarazu, Chiba 292-0818, Japan |
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| Abstract: | Altered hepatocellular focus was histopathologically observed in the liver of a 6-week-old Sprague-Dawley rat. The hepatocytes within this lesion had diffusely eosinophilic cytoplasm with scattered basophilia and slightly enlarged nuclei with prominent nucleoli. Based on these cytological characteristics, the lesion of these hepatocytes was classified as an amphophilic focus. This is the first report to describe spontaneous amphophilic focus in a young rat. |
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