Epicardial fat thickness significantly decreases after short-term growth hormone (GH) replacement therapy in adults with GH deficiency |
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Authors: | E. Ferrante A.E. Malavazos C. Giavoli F. Ermetici C. Coman S. Bergamaschi E. Profka S. Briganti C.L. Ronchi E. Passeri S. Corbetta A.G. Lania A. Spada G. Iacobellis B. Ambrosi P. Beck-Peccoz |
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Affiliation: | 1. Endocrinology and Diabetology Unit, Department of Medical Sciences, University of Milan, Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico, Milan, Italy;2. Diabetology and Metabolic Disease Unit, IRCCS Policlinico San Donato, San Donato Milanese, Italy;3. Echocardiographic Unit, IRCCS Policlinico San Donato, San Donato Milanese, Italy;4. Endocrinology and Diabetology Unit, Department of Medical and Surgical Sciences, University of Milan, IRCCS Policlinico San Donato, San Donato Milanese, Italy;5. Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, FL, USA |
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Abstract: | Background and AimGrowth Hormone Deficiency (GHD) is characterized by increased visceral fat accumulation. Echocardiographic epicardial fat thickness is a new marker of visceral adiposity. Aim of the present study was to evaluate whether epicardial fat thickness can significantly change and therefore serve as a marker of visceral fat reduction after short-term rhGH replacement therapy in patients with adult-onset GHD.Methods and ResultsEchocardiographic epicardial fat thickness was measured in 18 patients (10 M, 8 F, age 48 ± 11.8 yrs, BMI 29 ± 5.9 kg/m2) with adult-onset GHD, at baseline and after 6 and 12 months of rhGH therapy and in 18 healthy matched controls, at baseline. Echocardiographic epicardial fat thickness, conventional anthropometric and metabolic parameters, body fat percentage and quality of life were also evaluated. Epicardial fat thickness in adult GHD patients was higher than in controls (9.8 ± 2.8 vs 8 ± 3 mm, p < 0.05). Epicardial fat thickness significantly decreased after 6-months of rhGH replacement therapy (from 9.8 ± 2.8 to 7.0 ± 2.3 mm, P < 0.01, i.e. ?29% from baseline). After 12 months of rhGH replacement therapy, epicardial fat thickness showed a further significant decrease (from 7.0 ± 2.3 to 5.9 ± 3.1 mm, P < 0.01, i.e. ?40% from baseline). No significant changes in BMI or waist circumference after 6 or 12 months of rhGH therapy were observed.ConclusionsEchocardiographic epicardial fat thickness may represent a valuable and easy marker of visceral fat and visceral fat changes during rhGH replacement treatment in patients with adult-onset growth hormone deficiency. |
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