| 心脏芯片研究进展 |
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| 引用本文： | 陈颖(综述),付炜(审校). 心脏芯片研究进展[J]. 组织工程与重建外科, 2021, 0(1): 66-69 |
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| 作者姓名： | 陈颖(综述) 付炜(审校) |
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| 作者单位： | 上海交通大学医学院附属上海儿童医学中心;上海市组织工程重点实验室 |
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| 基金项目： | 上海市浦江人才计划(18PJD031);上海交通大学医工交叉项目(YG2016MS28);上海交通大学医学院转化医学协同创新中心合作研究项目(TM201821)。 |
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| 摘 要： | 为了降低药物开发的成本,以及对心脏特定疾病的发生发展进行准确的临床预测并制订个性化的治疗方案,需要开发相关的体外试验平台.这个平台既要具备高度精确性,能模拟复杂的心脏微环境,又要保证操作简易、经济成本低廉,心脏芯片应运而生.心脏芯片利用其精细的结构,精确模拟体内环境,大大提升了体外试验平台的可靠程度,成为未来心脏组织工...
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| 关 键 词： | 心脏芯片 微流控平台 微型器 |
Research Progress of Microfluidic Heart On A Chip |
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| Affiliation: | (Institute of Pediatric Translational Medicine,Shanghai Jiao Tong University,Shanghai 200127,China;Department of Pediatric Cardiothoracic Surgery,Shanghai Children's Medical Center,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China;Shanghai Key Laboratory of Tissue Engineering,Shanghai 200011,China) |
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| Abstract: | In order to reduce the cost of drug development,and make accurate clinical prediction of the occurrence and development of specific heart diseases and formulate personalized treatment plans,it is necessary to develop a relevant in vitro experimental platform with high accuracy.It can simulate the complex cardiac microenvironment exactly,and ensure easy operation and low economic cost.The heart chip comes into being.The heart chip uses its fine structure to accurately simulate the in vivo environment,which greatly improves the reliability of the in vitro experimental platform and becomes one of the most important development directions in the field of heart tissue engineering in the future.In this paper,the basic composition and optimization of the heart chip were reviewed. |
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| Keywords: | Heart on a chip Microfluidic platform Microphysiological devices |
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