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Glucosamine alleviates scopolamine induced spatial learning and memory deficits in rats |
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| Authors: | Khadijeh Jamialahmadi Hamid Reza Sadeghnia Ghazaleh Mohammadi Ali Masoudi Kazemabad Mahmoud Hosseini |
| Affiliation: | 1. Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;2. Neurocognitive Research Center and Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;3. Department of Biology, Payam Noor University of Mashhad, Mashhad, Iran;4. Department of Biology, Islamic Azad University, Science and Research Branch, Tehran, Iran;5. Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;6. Applied Physiology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran |
| Abstract: | Introduction and objectiveBeneficial effects of glucosamine in spatial learning and memory impairment induced by scopolamine has been evaluated in rats by using Morris water maze.MethodsMale Wistar rats were randomly divided into control, scopolamine and scopolamine plus glucosamine groups. All injections were given in 5 consecutive days and 30 min after each injection, the rats were tested in the Morris water maze test. Escape latency and path length to reach the hidden platform were subjected to analysis of variance [ANOVA].ResultsThe rats treated with scopolamine showed increased escape latency and path length to reach the hidden platform compared to control group (P < 0.001). Both escape latency and traveled path length to reach the hidden platform in glucosamine treated animals (1 and 2 g/kg) were significantly lower (P < 0.05 to P < 0.001) than in the scopolamine group.ConclusionThe results of this study showed that the glucosamine can inhibit scopolamine-induced impairments of spatial learning and memory in rats. Glucosamine might offer a promise in either the prevention or the treatment of neurodegenerative diseases such as Alzheimer's disease. |
| Keywords: | Scopolamine Morris water maze Spatial learning and memory Male rats |
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